Tomislav Rovis

Tomislav Rovis

Research Interest


Over the course of the past greater decade, our research here at the Rovis group has covered a broad range of topics in asymmetric catalysis, organocatalysis, and organometallic chemistry. Since its inception, our group has disclosed findings ranging from the stereoselective rearrangements of vinyl acetals and ethers, to Ni-catalyzed desymmetrizations of various cyclic meso-anhydrides, and even disclosing the synthesis of several natural products using various technologies developed within the lab. We also have a rich and prominent history within the field of N-heterocyclic carbenes (NHCs) as organocatalysts, pioneering studies in acyl-anion, azolium-enolate, and homoenolate reactivities as catalyzed by triazolylidene-based carbenes. We use the methodology developed within our group to provide easier access to nitrogen and oxygen containing heterocycles, those of which are of significant interest to the fields of medicinal chemistry and pharmaceutical development.

Late-Stage N-Me Selective Arylation of Trialkylamines Enabled by Ni/Photoredox Dual Catalysis
Yangyang Shen and Tomislav Rovis*
J. Am. Chem. Soc. 2021, 143, 40, 16364–16369

Rh(III)-Catalyzed Three-Component Syn-Carboamination of Alkenes Using Arylboronic Acids and Dioxazolones
Sumin Lee and Tomislav Rovis*
ACS Catal. 2021, 11, 14, 8585–8590

Copper Catalyzed C(sp3)–H Bond Alkylation via Photoinduced Ligand-to-Metal Charge Transfer
Sean M. Treacy and Tomislav Rovis*
J. Am. Chem. Soc. 2021, 143, 7, 2729–2735

Development of a Platform for Near-Infrared Photoredox Catalysis
Benjamin D. Ravetz, Nicholas E. S. Tay, Candice L. Joe*, Melda Sezen-Edmonds, Michael A. Schmidt, Yichen Tan, Jacob M. Janey, Martin D. Eastgate, and Tomislav Rovis*
ACS Cent. Sci. 2020, 6, 11, 2053–2059

Photoredox-Catalyzed Deaminative Alkylation via C–N Bond Activation of Primary Amines
Melissa A. Ashley, Tomislav Rovis
J. Am. Chem. Soc. 2020, 142, 43, 18310–18316

A site-selective amination catalyst discriminates between nearly identical C–H bonds of unsymmetrical disubstituted alkenes
Honghui Lei, Tomislav Rovis
Nat. Chem. 2020, 12, 725-731

Direct Regio‐ and Diastereoselective Synthesis of δ ‐Lactams from Acrylamides and Unactivated Alkenes Initiated by Rh(III)‐Catalyzed C−H Activation
Sumin Lee, Natthawat Semakul, Tomislav Rovis
Angew. Chem. Int. Ed. 2020, 59 , 4965.

Ligand Controlled Ir-Catalyzed Regiodivergent Oxyamination of Unactivated Alkenes
Honghui Lei, John H. Conway Jr., Caleb C. Cook, and Tomislav Rovis
J. Am. Chem. Soc. 2019, 141, 30, 11864-11869

Rh(III)-Catalyzed C-H Activation-Initiated Directed Cyclopropanation of Allylic Alcohols
Erik J. T. Phipps and Tomislav Rovis
J. Am. Chem. Soc. 2019, 141, 6807-6811

Asymmetric delta-Lactam Synthesis with a Monomeric Streptavidin Artificial Metalloenzyme
Isra S. Hassan, Angeline N. Ta, Michael W. Danneman, Natthawat Semakul, Matthew Burns, Corey H. Basch, Vanessa N. Dippon, Brian R. McNaughton, and Tomislav Rovis
J. Am. Chem. Soc. 2019, 141, 4815-4819

Photoredox catalysis using infrared light via triplet fusion upconversion
Benjamin D. Ravetz, Andrew B. Pun, Emily M. Churchill, Daniel N. Congreve, Tomislav Rovis & Luis M. Campos
Nature. 2019, 565, 343-346