Past Event

Chemistry Colloquium, Presented by Prof. Nozomi Ando

March 30, 2023
4:30 PM - 5:30 PM
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Havemeyer 209

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Correlated Atomic Displacements in Proteins

Presented by Nozomi Ando
Hosted by Milan Delor


Correlated motions in proteins arising from the collective movements of residues have long been proposed to be fundamentally important to key properties of proteins, from catalysis and allostery to evolvability. Recent breakthroughs in structural biology have made it possible to capture proteins undergoing complex conformational changes, yet the subtle and intrinsic fluctuations within a single conformation remain one of the least understood facets of protein structure. For many decades, the analysis of diffuse X-ray scattering held the promise of animating crystal structures with such correlated motions. With recent advances in both X-ray detectors, this long-held promise can now be met. In this talk, I’ll describe our recent work in interpreting this signal and discuss how it can be used to probe structural fluctuations that give rise to fundamental protein properties.

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