Events

Abstract: Pyridines and diazines are ubiquitous in pharmaceuticals; however, there are limitations in synthetic methods that can directly transform these structures in ways useful for medicinal chemists. This presentation will show three distinct approaches to functionalize these key heterocycles. We use the unique reactivity of phosphorus intermediates and phosphorus ligand-coupling reactions to enable periphery modification. A ring-opening, ring-closing strategy allows us to temporarily dearomatize pyridines and facilitates a new suite of reactions. Finally, through a deconstruction-reconstruction approach, we have shown a new approach for molecule diversification that functions on pharmaceutical matter. Mechanistic and computational studies support this journey in heterocyclic chemistry. 

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