Biophotonics is one of the fastest growing fields at the interface of physical science and life science. The emerging biophotonics tools promise to make major contributions in unraveling biological processes that are localized in space, dynamic in time, and complex in nature. The Min group is dedicated to develop next-generation optical spectroscopy and microscopy techniques and to apply them to visualize and understand dynamic behaviors of bio-molecules and their delicate interactions in living cells and organisms. Advances in synthetic chemistry and chemical biology will be integrated with novel optics and spectroscopy.
Hu, C. Zeng, R. Long, Y. Miao, L. Wei, Q. Xu and W. Min. Super-multiplexed optical imaging and barcoding with engineered polyynes. Nature Methods, 15, 194 (2018).
Shi, C. Zheng, Y. Shen, Z. Chen, E. Silveira, L. Zhang, M. Wei, C. Liu, C. de Sena-Tomas, K. Targoff and W. Min. “Optical imaging of metabolic dynamics in animals”, Nature Communications, 9, 2995 (2018).
Cheng, L. Wei, Z. Liu, N. Ni, Z. Sang, B. Zhu, W. Xu, L.-Q. Chen, W. Min* and Y. Yang*. “In-operando, three dimensional, and simultaneous visualization of ion depletion and lithium growth by stimulated Raman scattering microscopy”, Nature Communications, 9, 2942 (2018) *Co-corresponding authors.
L. Wei, Z. Chen, L. Shi, R. Long, A. V. Anzalone, L. Zhang, F. Hu, R. Yuste, V. W. Cornish and W. Min. “Super-multiplex vibrational imaging”, Nature, 544, 465 (2017).
Y. Shen, Z. Zhao, L. Zhang, L. Shi, S. Shahriar, R. B. Chan, G. Paolo and W. Min. “Metabolic activity induces membrane phase separation in endoplasmic reticulum”, Proc. Natl. Acad. Sci. USA 114, 13394 (2017)
L. Wei, F. Hu, Z. Chen, Y. Shen, L. Zhang and W. Min. “Live-cell bioorthogonal chemical imaging: stimulated Raman scattering microscopy of vibrational tags”, Acc. Chem. Res. 49, 1494 (2016).
F. Hu, Z. Chen, L. Zhang, Y. Shen, L. Wei and W. Min. “Vibrational imaging of glucose uptake activity in live cells and tissues by stimulated Raman scattering”, Angew. Chem. Int. Ed. 54, 9821 (2015)
L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. Lin, M. Wang and W. Min. “Live-cell imaging with alkyne-tagged small biomolecules by stimulated Raman Scattering”, Nature Methods, 11, 410 (2014).
Z. Chen, D. Paley, L. Wei, A. Weisman, R. Friesner, C. Nuckolls and W. Min. “Multicolor live-cell chemical imaging by isotopically edited alkyne vibrational palette”, J. Am. Chem. Soc. 136, 8027 (2014).
L. Wei, Y. Yu, Y. Shen, W. C. Wang and W. Min. “Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy”, Proc. Natl. Acad. Sci. USA 110, 11226 (2013).
W. Min, C.W. Freudiger, S. Lu, and X. S. Xie. “Coherent nonlinear optical imaging: beyond fluorescence mi- croscopy”, Rev. Phys. Chem., 62, 506, (2011).
W. Min, S. Lu, S. Chong, Rahul, G. H. Holtom and X. S. Xie. “Imaging chromophores with undetectable fluorescence by simulated emission microscopy”, Nature, 461, 1105, (2009).
C.W. Freudiger,W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C.Tsai, J. X. Kang and X. S. Xie. “Label- free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy”, Science, 322, 1857, (2008).