Events

Altered Cross-Coupling Reactions

Cross-coupling reactions are central to modern synthesis because they link abundant building blocks. Our group seeks to design catalytic reactions that repurpose conventional coupling partners to access alternative, useful products. In this seminar, we will discuss aminative Suzuki–Miyaura coupling and related oxygenative and carbenylative variants, in which formal atom or group insertion changes a C–C bond-forming manifold into a direct route to heteroatom- and carbene-linked products. Second, we will present migratory aryl cross-coupling reactions that use reversible arylpalladium isomerization through mild metal-aryne formation to redirect the regioselectivity of cross-coupling. Third, we will introduce a strategy for integrating photoredox activation with palladium catalysis. These conjugates achieve nucleophilic fluorination reactions under extremely mild conditions. Together, these studies show how modifications of familiar catalytic cycles can offer new tools for diversity generation in chemical discovery.